In mammals, male sex determination, as well as spermatogenesis, is controlled by genes on the Y chromosome. Evolutionary comparisons may be used to detect and test candidate genes for these functions, under the hypothesis that the rapid evolution of the mammalian Y chromosome causes it to contain fe
Mammalian sex-determining genes
โ Scribed by Peter Koopman
- Book ID
- 103978399
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 411 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0958-1669
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โฆ Synopsis
The recent cloning of the Y-linked sex-determining gene SRY has ended one of the most notorious gene hunts in mammalian molecular genetics. Attention has now been turned to characterizing this gene further and studying how it acts as a switch in the choice of male or female developmental pathways.
๐ SIMILAR VOLUMES
The SRY gene on the mammalian Y chromosome undoubtedly acts to determine testis, but it is still quite unclear how. It was originally supposed that SRY acts directly to activate other genes in the testis-determining pathway. This paper presents an alternative hypothesis that SRY functions indirectly