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Mammalian Raf-1 is activated by mutations that restore Raf signaling in Drosophila

โœ Scribed by Cutler Jr, R. E.

Book ID
111745333
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
267 KB
Volume
16
Category
Article
ISSN
0261-4189

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## Abstract To investigate the role of Rafโ€1 in vโ€Haโ€ras transformation, we have isolated and characterized a number of Rafโ€1 mutants that display increased transforming activity in Rat2 fibroblasts. A dipeptide deletion (ฮ”144โ€“145) in the cysteineโ€rich domain (CRD) of conserved region (CR) 1 increa