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P21Cip1 induced by Raf is associated with increased Cdk4 activity in hematopoietic cells

โœ Scribed by Chang, Fumin; McCubrey, James A


Book ID
110064829
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
390 KB
Volume
20
Category
Article
ISSN
0950-9232

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โœ Hanako Kobayashi; Er Mei Tan; Sharon E. Fleming ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 331 KB

## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s