𝔖 Bobbio Scriptorium
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Mammalian histidine decarboxylase: from structure to function

✍ Scribed by Aurelio A. Moya-Garcia; Miguel Ángel Medina; Francisca Sánchez-Jiménez

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
269 KB
Volume
27
Category
Article
ISSN
0265-9247

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✦ Synopsis

Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and highly prevalent pathologies. Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC 4.1.1.22), an enzyme that still remains to be fully characterized. Nevertheless, during the last few years, important advances have been made in this field, including the generation and validation of the first threedimensional model of the enzyme, which allows us to revisit previous results and conclusions. This essay provides a comprehensive review of the current knowledge of the structural and functional characteristics of mammalian histidine decarboxylase.

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