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Mammalian EGF receptor activation by the rhomboid protease RHBDL2

✍ Scribed by Adrain, Colin; Strisovsky, Kvido; Zettl, Markus; Hu, Landian; Lemberg, Marius K; Freeman, Matthew


Book ID
109851718
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
661 KB
Volume
12
Category
Article
ISSN
1469-221X

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## Abstract Factor Xa (FXa) elicits intracellular signaling responses through the activation of protease‐activated receptor 2 (PAR2) and possibly also through PAR1 in endothelial cells. In this study, we investigated FXa signaling in endothelial cells when the protease was either in free form or as