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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

✍ Scribed by Rozakis-Adcock, Maria; Fernley, Ross; Wade, John; Pawson, Tony; Bowtell, David

Book ID: 109784118
Publisher: Nature Publishing Group
Year: 1993
Tongue: English
Weight: 432 KB
Volume: 363
Category: Article
ISSN: 0028-0836
DOI: 10.1038/363083a0

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## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20–30% of breast