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Mammalian cell transformation and aneuploidy induced by five bisphenols

✍ Scribed by Takeki Tsutsui; Yukiko Tamura; Ayako Suzuki; Yutaka Hirose; Morio Kobayashi; Hiroyuki Nishimura; Manfred Metzler; J. Carl Barrett

Publisher
John Wiley and Sons
Year
2000
Tongue
French
Weight
75 KB
Volume
86
Category
Article
ISSN
0020-7136

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✦ Synopsis

Bisphenol-A (BP

-A), a monomer of plastics used in numerous consumer products and a xenoestrogen, induces cellular transformation and aneuploidy in Syrian hamster embryo (SHE) cells. In this study, the abilities of 4 other bisphenols to induce cellular transformation and genetic effects in SHE cells were examined and compared to BP-A. Cellular growth was inhibited by all bisphenols in a concentration-related manner. The growth inhibitory effect of the bisphenols ranked: BP-5 > BP-4 > BP-3 > BP-2 or BP-A. Morphological transformation of SHE cells was induced by BP-A, BP-3, BP-4 and BP-5, and the induced-transformation frequencies were highest with BP-4. None of the bisphenols induced gene mutations at the Na Ψ‰ /K Ψ‰ ATPase locus or the hprt locus, or chromosomal aberrations in SHE cells. By contrast, aneuploidy induction in the near-diploid range was exhibited by BP-A, BP-3, BP-4 or BP-5, corresponding to the transforming activity of each compound. The results indicate that BP-A, BP-3, BP-4 and BP-5 exhibit transforming activity in SHE cells, while BP-2 does not, and that aneuploidy induction may be a causal mechanism of the transforming activity. Int.

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