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Mammalian brain dihydrofolate reductase

โœ Scribed by R. Lynn; M. E. Rueter; R. W. Guynn


Book ID
111169632
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
206 KB
Volume
29
Category
Article
ISSN
0022-3042

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Dihydrofolate reductase-activity in brai
โœ Ludwig, Rolf ;Frei, Eva ;Kimmig, Bernhard ;Brandeis, Werner E. ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer-Verlag โš– 310 KB

The mechanism responsible for the toxic late effects of cranial irradiation, followed by the administration of systemic methotrexate (MTX) on brain tissue, is still under discussion. We studied the influence of X-irradiation on dihydrofolate reductase (E.C. 1.5.1.3) activity (DHFR), the enzyme inhib