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Malonyl-CoA: acetyl-CoA cycling. A new micromethod for determination of acyl-CoAs with malonate decarboxylase

โœ Scribed by Yoshichika Takamura; Yoshiharu Kitayama; Akio Arakawa; Sayuri Yamanaka; Masako Tosaki; Yukie Ogawa


Book ID
115739260
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
619 KB
Volume
834
Category
Article
ISSN
0005-2760

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A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elev