Design and synthesis of a new class of m
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Haifeng Tang; Yan Yan; Zhe Feng; Reynalda K. de Jesus; Lihu Yang; Dorothy A. Lev
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Article
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2010
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Elsevier Science
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English
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A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elev