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Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of gujarat, india

✍ Scribed by Sol Silverman jr.; K. Bhargava; N. J. Mani; Lowell W. Smith; A. M. Malaowalla

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 441 KB
Volume: 38
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197610)38:4<1790::aid-cncr2820380456>3.0.co;2-i

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✦ Synopsis

In Gujarat, India, 6718 industrial workers, over 35 years of age, with oral leukoplakia (confirmed clinically and microscopically), were studied. After 2 years, 4762 (71%) of the individuals were re-examined. The buccal mucosa was the most common site of occurrence; 98.3% of these individuals had oral habits, with smoking alone or smoking in combination with "pan" or "supari" chewing accounting for 74.9% of the habit forms. Six individuals (0.13%) with oral leukoplakia developed oral carcinomas within 2 years. This incidence of malignant transformation was equivalent to 63/100,000 per year, which far exceeds that of new oral cancers expected even in high-risk populations. While 57.3% the leukoplakic lesions remained unchanged during a 2-year interval, 31.6% disappeared and 11% had an altered appearance. This study confirmed the precancerous nature of oral leukoplakia.

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Oral cancer in 57,518 industrial workers

Oral cancer in 57,518 industrial workers of Gujarat, India. A prevalence and followup study

✍ A. M. Malaowalla; Sol Silverman Jr.; N. J. Mani; K. F. Bilimoria; Lowell W. Smit 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB

I n Gujarat, India, 57,518 industrial workers over 35 years old were examined for oral lesions. At a two-year interval, 43,654 workers were re-examined. Biopsies were taken from 13,223 lesions. I n the initial examination, 29 oral cancers were diagnosed, representing a prevalence rate of 50/100,000.