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Malignant peripheral primitive neuroectodermal tumor-peripheral neuroepithelioma of the head and neck: A clinicopathologic study of five cases and review of the literature

✍ Scribed by Nikolaos G. Nikitakis; Andrew R. Salama; Bert W. O'Malley Jr; Robert A. Ord; John C. Papadimitriou

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
547 KB
Volume
25
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background.

The term primitive neuroectodermal tumor (PNET) encompasses a number of neoplasms of common neuroectodermal origin, but of variable clinical, histopathologic, ultrastructural, and molecular characteristics. Here, we focus on one particular member of the PNET family, the malignant peripheral PNET (pPNET) or peripheral neuroepithelioma of head and neck.

Methods.

Five patients diagnosed with malignant pPNET–peripheral neuroepithelioma of head and neck were included in the study. All existing literature was reviewed.

Results.

The diagnosis of malignant pPNET–peripheral neuroepithelioma of the head and neck was confirmed in all five cases. All patients are alive after treatment with a combination of therapeutic modalities; only one patient had metastatic disease develop. A literature review revealed another 38 reported cases.

Conclusions.

Malignant pPNET–peripheral neuroepithelioma should be included in the differential diagnosis of small, round, blue cell tumors of head and neck. A combination of multiple diagnostic modalities is essential for correct diagnosis, and multimodality treatment offers the best outcome. © 2003 Wiley Periodicals, Inc. Head Neck 25: 488–498, 2003

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