Malignant peripheral nerve sheath tumors of the head and neck: A clinicopathological study

✍ Scribed by Dr. Durga Swaroop Vege; Roshan Farokh Chinoy; Balasubramaniam Ganesh; Deepak Mukund Parikh

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 358 KB
• Volume: 55
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930550208

✦ Synopsis

h d i a

Twenty-seven cases of malignant peripheral nerve sheath tumors involving the head and neck region over a period of 7 years were reviewed. They were graded from 1-3 based on necrosis, mitosis, cellularity, and pleomorphism. Mean age of occurrence was 42 years, with a range of 12-70 years. Male preponderance was noted (M:F = 3.5:l). The most common site of involvement was the neck (44.6%). The main presenting symptom was an enlarging mass. The nerve of origin could be identified in 33% of patients. Treatment consisted of wide excision. The 5-year observed survival was 33%. Fifty-two percent of patients developed local recurrence of disease. Fifteen percent of patients died due to advanced local disease within 18 months of treatment. Distant metastasis was seen in 18.5% of patients. Lymph node metastasis was not seen. At the end of 5 years 15% of patients remained disease free. Large tumor size (>5 cm) adversely affected the prognosis ( P = <O. 1). No significant correlation was noted between the grade of tumor and survival. 0