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Malignant pediatric intracerebral nerve sheath tumor in neurofibromatosis type 1

✍ Scribed by Seyyed Ali Nabavizadeh; Arastoo Vossough


Publisher
Springer
Year
2009
Tongue
English
Weight
46 KB
Volume
25
Category
Article
ISSN
0256-7040

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Neurofibromatosis type 1 (NF1) patients have 10% of lifetime risk for developing malignant peripheral nerve sheath tumors (MPNST), one of the most aggressive cancers. We examined the spectrum of constitutional NF1 mutations among 24 NF1 patients with MPNST. We found mutations in 18 patients: four me