Malignant intracerebral giant nerve sheath tumor in a 14-month-old girl with neurofibromatosis type 1
✍ Scribed by Namik Öztanır
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 38 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0256-7040
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## Abstract Telomerase activity (TA) and the expression of its enzymatic subunits, which have been demonstrated in many tumors, remain poorly investigated in tumors associated with neurofibromatosis type 1 (NF1). In this study, we analysed the association of TA and the expression of telomerase RNA
Neurofibromatosis type-1 (NF1) is associated with the growth of benign and malignant tumors. Approximately 15% of NF1 patients develop malignant peripheral nerve sheath tumors (MPNSTs), underlining the need to identify specific diagnostic/prognostic biomarkers associated with MPNST development. The