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Malignant melanoma in a woman with LEOPARD syndrome: identification of a germline PTPN11 mutation and a somatic BRAF mutation

✍ Scribed by M. Seishima; Y. Mizutani; Y. Shibuya; C. Arakawa; R. Yoshida; T. Ogata


Book ID
108669720
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
545 KB
Volume
157
Category
Article
ISSN
0007-0963

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## Abstract ## BACKGROUND Nonsyndromic hypertrophic cardiomyopathy (HCM) is a primary cardiac disease transmitted as an autosomal dominant trait. Multiple chromosomal loci have been found to be involved in the etiology of this defect. LEOPARD syndrome is a genetic condition characteristically asso