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Maleic hydrazide as an antimetabolite of uracil

✍ Scribed by D. Coupland; A. J. Peel

Book ID
104750363
Publisher
Springer-Verlag
Year
1972
Tongue
English
Weight
252 KB
Volume
103
Category
Article
ISSN
0032-0935

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✦ Synopsis

When labelled uracil was supplied to the solution bathing the cambial surfaces of bark strips of willow, uptake into the sieve elements f~ok place as evidenced by the appearance of radioactivity in the honeydew of aphids feeding on the strips. When maleic hydrazide (MH) was also applied an inhibition of uracil uptake was observed. However uracil seemed to have no effect on MH uptake. The type of inhibition described above showed similarities to classical competitive inhibitors of enzymes.

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## Abstract A molecular packing analysis of the hydrogen‐bonded layer structure of maleic hydrazide shows that even in such a structure, the van der Waals energy is the dominant component of the lattice energy. The hydrogen‐bond energy of the observed structure is greater than that for alternative