Malathion detoxification by human hepati
โ
Franca M. Buratti; Emanuela Testai
๐
Article
๐
2006
๐
John Wiley and Sons
๐
English
โ 205 KB
The organophosphorothioate (OPT) pesticide malathion (MAL) in mammals is readily hydrolyzed by mammalian carboxylesterases (CE). The reaction competes with the CYP-catalyzed formation of malaoxon (MOX), the toxic metabolite. Alterations or individual variations in CE activity may result in increased