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Malathion carboxylesterase activity in human liver and its inactivation by isomalathion

โœ Scribed by R.E. Talcott; H. Denk; N.M. Mallipudi


Book ID
116072481
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
326 KB
Volume
49
Category
Article
ISSN
0041-008X

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โœ Franca M. Buratti; Emanuela Testai ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 205 KB

The organophosphorothioate (OPT) pesticide malathion (MAL) in mammals is readily hydrolyzed by mammalian carboxylesterases (CE). The reaction competes with the CYP-catalyzed formation of malaoxon (MOX), the toxic metabolite. Alterations or individual variations in CE activity may result in increased