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Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver

✍ Scribed by Renato Sampaio Carvalho; Karen Friedrich; Ana C.A.X. De-Oliveira; Guilherme Suarez-Kurtz; Francisco J.R. Paumgartten

Book ID
113588305
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
282 KB
Volume
616
Category
Article
ISSN
0014-2999

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## Abstract We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model to identify CYP‐mediated mechanisms underlying age‐dependent differences in susceptibility to toxicity. We evaluated CYP expressi