Major histocompatibility complex class II-associated peptides determine the binding of the superantigen toxic shock syndrome toxin-1
โ Scribed by Arne von Bonin; Svenja Ehrlich; Georg Malcherek; Bernhard Fleischer
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 449 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
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Previous studies have shown that the presentation of some bacterial superantigens by major histocompatibility complex (MHC) class II molecules is strongly influenced by class II-associated peptides. For example, presentation of the toxic shock syndrome toxin-1 (TSST-1) superantigen by antigen-proces
## Abstract The activation of helper T cells by peptides bound to proteins of the class II Major Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The primary functional requirement imposed on MHC II proteins is the ability to efficiently bind thousands of diff