Magnetic resonance imaging morphology of the corpus callosum in monozygotic twins

✍ Scribed by Jeffrey S. Oppenheim; John E. Skerry; Dr Michael S. Gazzaniga

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 442 KB
• Volume: 26
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.410260117

✦ Synopsis

It is well established in HNPP that seemingly unaffected individuals or patients with only focal symptoms can show widespread electrophysiological abnormalities that point to a diffuse subclinical polyneuropathy 12-51. It is not certain whether our patient's histopathological findings were inherited or acquired. Family history was negative for neuropathy, no specific precipitating factor was apparent, and compression seemed unlikely. Thus, we believe that the tomaculous changes in our case were acquired. However, the possibility of a preceding subclinical polyneuropathy cannot be excluded with certainty. Interestingly, similar histological findings have been described in neuropathy associated with benign monoclonal gammopathy, suggesting an acquired basis in some cases [81.

Since exhaustive investigation revealed no other cause for our patient's symptoms, we postulate that tomaculous change is the important association. When tomaculous change first occurred cannot be stated. We believe that this case is unique and broadens the clinical spectrum of TN, which may not always manifest as recurrent hereditary mononeuropathy or brachial plexopathy.