## Abstract Our objective was to investigate thalamic neuronal dysfunction in patients with Huntington disease (HD). We performed localized singleβvoxel proton magnetic resonance spectroscopy (MRS) of the thalamus in 22 HD patients and 25 healthy individuals. The mean age of patients was 48.5 years
Magnetic resonance imaging and proton spectroscopy in the Huntington disease
β Scribed by Sarac, H.; Telarovic, S.
- Book ID
- 122817066
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 58 KB
- Volume
- 333
- Category
- Article
- ISSN
- 0022-510X
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## Abstract The gene responsible for Huntington's disease (HD) has been located, but its action and the pathophysiology of HD remain unclear. Glutamate excitotoxicity may contribute to the striatal neurodegeneration seen in HD. We used localised proton magnetic resonance spectroscopy (MRS) of the b