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Evidence for glutamate excitotoxicity in Huntington's disease with proton magnetic resonance spectroscopy

✍ Scribed by SimonD. Taylor-Robinson; RobertA. Weeks; Janet Sargentoni; ClaudeD. Marcus; DavidJ. Bryant; AnitaE. Harding; DavidJ. Brooks


Book ID
118554228
Publisher
The Lancet
Year
1994
Tongue
English
Weight
131 KB
Volume
343
Category
Article
ISSN
0140-6736

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Proton magnetic resonance spectroscopy i
✍ Dr. S. D. Taylor-Robinson; R. A. Weeks; D. J. Bryant; J. Sargentoni; C. D. Marcu πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 927 KB

## Abstract The gene responsible for Huntington's disease (HD) has been located, but its action and the pathophysiology of HD remain unclear. Glutamate excitotoxicity may contribute to the striatal neurodegeneration seen in HD. We used localised proton magnetic resonance spectroscopy (MRS) of the b

Evidence of thalamic dysfunction in Hunt
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## Abstract Our objective was to investigate thalamic neuronal dysfunction in patients with Huntington disease (HD). We performed localized single‐voxel proton magnetic resonance spectroscopy (MRS) of the thalamus in 22 HD patients and 25 healthy individuals. The mean age of patients was 48.5 years