Magnesium pemoline: Effects of a broad range of doses on water maze performance

✍ Scribed by James E. McCarroll; Susan F. Korbel

• Book ID: 104759505
• Publisher: Springer
• Year: 1972
• Tongue: English
• Weight: 557 KB
• Volume: 24
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00403649

✦ Synopsis

60 rats were given doses of 20, 60 or 100 mg/kg of magnesium pemoline or a placebo. They were tested (1 trial a day) for 21 days of drug treatment and for 10 days of no treatment. It was found that drug-treated animals had a significantly lower total time in the maze on some days of the experiment; however, the swimming time of the drug groups was often higher than that of the placebo group. Experimental subjects also made more errors and had higher percentages of swimming time than placebo-treated subjects. The number of errors and percent swimming time increased with increasing drug doses. Drug-treated subjects had higher activity scores and less weight gain than placebo subjects. The weight changes were reversed after drug treatment was discontinued.