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Macrophages: SOCS2 and SOCS3 in macrophage polarization

✍ Scribed by Papatriantafyllou, Maria

Book ID
118161559
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
83 KB
Volume
13
Category
Article
ISSN
1474-1741

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## Abstract Suppressor of cytokine signaling‐3 (SOCS3) has multiple functions including inhibition of Janus kinase (Jak) activity, regulation of protein degradation, and suppression of cytokine signaling. SOCS3 modulates macrophage response to cytokines such as IL‐6 and leptin that are systemically