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IL-10 attenuates IFN-α-activated STAT1 in the liver: involvement of SOCS2 and SOCS3

✍ Scribed by Xuening Shen; Feng Hong; Van-Anh Nguyen; Bin Gao

Book ID: 117102175
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 227 KB
Volume: 480
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(00)01905-0

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator