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The intrinsic inhibitors of JAK/STAT pathway, CIS3/SOCS3/SSI3 and JAB/SOCS1/SSI1, play a negative regulatory role in STAT3 activation and intestinal inflammation

✍ Scribed by Asuka Suzuki; Keiichi Mitsuyama; Nobuo Tomiyasu; Kosuke Takagi; Atsushi Toyonaga; Akihiko Yoshimura; Michio Sata

Book ID: 119428970
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 186 KB
Volume: 120
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(08)80103-5

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator