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Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors

โœ Scribed by Izumi Yawata; Hideyuki Takeuchi; Yukiko Doi; Jianfeng Liang; Tetsuya Mizuno; Akio Suzumura


Book ID
116719367
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
729 KB
Volume
82
Category
Article
ISSN
0024-3205

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## Abstract Extracellular glutamate is kept below a toxic level by glial and neuronal glutamate transporters. Here we show that the transportable glutamate uptake inhibitor Lโ€__trans__โ€pyrrolidineโ€2,4โ€dicarboxylate (__t__โ€PDC) induced cell death in mature, but not in immature, hippocampal neuronโ€en