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Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa

✍ Scribed by Inoue, S; Riley, J; Gant, T W; Dyer, M J S; Cohen, G M

Book ID
110058270
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
346 KB
Volume
21
Category
Article
ISSN
0887-6924

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## Abstract Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of anti‐leukemic effects of an HDAC inhibitor (HDI), depsipeptide (FK228), using myeloid leukemia cel