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Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

✍ Scribed by Bangert, A; Cristofanon, S; Eckhardt, I; Abhari, B A; Kolodziej, S; Häcker, S; Vellanki, S H K; Lausen, J; Debatin, K-M; Fulda, S

Book ID
115533244
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
821 KB
Volume
31
Category
Article
ISSN
0950-9232

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## Abstract Histone‐deacetylase (HDAC) inhibitors (HDACi) can block proliferation and induce intrinsic apoptosis in human papillomavirus (HPV)‐positive cervical carcinoma cells, independently of copy number and integration locus of the viral DNA. Using HPV18‐positive HeLa cells as model systems, we