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Macrophage apoptosis in muscle tissue in experimental autoimmune myasthenia gravis

✍ Scribed by Fu-Dong Shi; Xue-Feng Bai; Hu-Lun Li; Hans Link

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
237 KB
Volume
21
Category
Article
ISSN
0148-639X

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✦ Synopsis

Combining in situ tailing and immunocytochemical staining, we demonstrated that the infiltrating macrophages in muscle tissue sections during early phase of experimental autoimmune myasthenia gravis (EAMG) in Lewis rats were eliminated by apoptosis at high frequency. These apoptotic macrophages were colocalized in the end-plate regions. Apoptosis is a major cause for elimination of infiltrating macrophages during the early phase of EAMG.

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