## Abstract Recent evidence indicates that in chronic experimental autoimmune myasthenia gravis (EAMG) and in human myasthenia gravis, the defect of neuromuscular transmission results from immuneβmediated destruction of postsynaptic membrane at the neuromuscular junction, with a reduction in the de
Lymphocyte responsiveness to acetylcholine receptor in rats with experimental autoimmune myasthenia gravis
β Scribed by Sadako A. Noguchi; Daniel B. Drachman; Robert N. Adams; Robert L. Hirsch
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 539 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0364-5134
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Myasthenia gravis (MG) is a neuromuscular disorder of man caused by a humoral response to the acetylcholine receptor (AChR). Most of the antibodies in MG and in experimental autoimmune myasthenia gravis (EAMG) are directed to the extracellular portion of the AChR alpha subunit, and within it, primar
## Antigen-specific therapy of experimental myasthenia gravis with acetylcholine receptor-gelonin conjugates in viva* Rats suffering from experimental autoimmune myasthenia gravis (EAMG) induced by previous immunization with foreign acetylcholine receptor (AChR) were treated with AChR-toxin conjug
A test for diminished neuromuscular function in animals with experimental autoimmune myasthenia gravis is described. Within minutes following an injection of gallamine triethiodide, mice exhibit a dramatic yet transient response which is dose-dependent. Mice previously inoculated with acetylcholine
Experimental autoimmune neuritis (EAN) is a CD4 Ψ T cell-mediated, inflammatory demyelinating disease of the peripheral nervous system (PNS) that serves as a model for Guillain-Barre Β΄syndrome (GBS) in humans. Various mouse and rat strains show different susceptibilities to EAN that can be induced b