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Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment

✍ Scribed by Ravelli, A; Grom, A A; Behrens, E M; Cron, R Q


Book ID
120334522
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
514 KB
Volume
13
Category
Article
ISSN
1466-4879

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## Abstract The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult‐onset Still's disease. Interleukin‐18 (IL‐18) in particular has been reported to be a candidate for the key cytokine in both diseases;