✦ LIBER ✦

Macrophage activation by T cells: cognate and non-cognate signals

✍ Scribed by Robert D. Stout

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 764 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90059-2

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✦ Synopsis

Both tumor necrosis factor-a and interferon-y are involved in the activation of macrophage cytocidal/cytostatic effector function. Recent studies provide evidence that, in non-septic inflammatory disease, T cells may activate macrophages primed by interferon-y either by providing tumor necrosis factor-a (in soluble or membrane-anchored form) or by inducing macrophage tumor necrosis factor-a production by antigen-non-specific cognate interactions. Conversely, T cells may inhibit macrophage activation by producing cytokines that inhibit either tumor necrosis factor-a production or interferon-y receptor signaling.

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