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Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E2 via toll-like receptor 2 in human placental trophoblast cells

✍ Scribed by Masahiro Mitsunari; Souichi Yoshida; Takako Shoji; Satoru Tsukihara; Tomio Iwabe; Tasuku Harada; Naoki Terakawa

Book ID: 113752582
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 676 KB
Volume: 72
Category: Article
ISSN: 0165-0378
DOI: 10.1016/j.jri.2006.02.003

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## Abstract Thrombin levels increase at sites of vascular injury and during acute coronary syndromes. It is also increased several fold by sepsis with a reciprocal decrease in the anti‐thrombin III levels. In this study we investigate the effects of thrombin on the induction of cyclooxygenase‐2 (CO