Macromolecular structure and reactivity: peptide synthesis using polymeric acyl transfer reagents

✍ Scribed by Aiswaryakumari, K.; Sreekumar, K.

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 237 KB
• Volume: 45
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/(sici)1097-0126(199803)45:3<255::aid-pi904>3.0.co;2-n

✦ Synopsis

The use of polystyrene-and polyacrolein-supported oximinoesters and oximinodithiocarbonic anhydrides in the synthesis of some peptides is illustrated. The efficiency of the peptide synthesis revealed a signiÐcant inÑuence of the nature of the support, nature of crosslinking agent and extent of crosslinking. An increase in the polarity and hydrophilicity of the macromolecular support invariably resulted in an increase in the yield of the peptide. Thus, tetraethyleneglycol diacrylate crosslinked polyacrolein support was found to be more efficient in e †ecting peptide synthesis than other polystyrene-based supports and divinylbenzene crosslinked polyacrolein support.

1998 SCI.