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Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes

✍ Scribed by Michiko Miyazaki; Masafumi Zaitsu; Kinji Honjo; Eiichi Ishii; Yuhei Hamasaki

Book ID
117641868
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
238 KB
Volume
69
Category
Article
ISSN
0952-3278

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We examined prostaglandin E2 (PGE2) biosynthetic heterogeneity in fibroblast substrains and possible mechanisms that might mediate this heterogeneity. PGEz synthesis of fibroblast substrains, in response to phytohemagglutinin-stimulated mononuclear cell supernates, ranged from 9.0 f 1.0 ng/ml to 79.