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Macroglobulinemia with peripheral neuropathy simulating motor neuron disease

✍ Scribed by Dr. Lewis P. Rowland; Richard Defendini; William Sherman; Asao Hirano; M. R. Olarte; Norman Latov; Robert E. Lovelace; Kiyoharu Inoue; Elliot F. Osserman

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
622 KB
Volume
11
Category
Article
ISSN
0364-5134

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✦ Synopsis

Abstract

A 48‐year‐old man with an IgM plasma cell dyscrasia died after 14 months of symptoms and signs typical of motor neuron disease, including widespread fasciculation and normal sensation. Two laboratory results were atypical: cerebrospinal fluid protein content of 132 mg/dl and slow motor nerve conduction. At autopsy, no loss or atrophy of anterior horn neurons was found; instead, degeneration of ventral and dorsal roots and retrograde changes of chromatolysis in motor neurons implied peripheral neuropathy. Most reported cases of neuropathy associated with plasma cell dyscrasias have been sensorimotor or purely sensory, but there have been 14 previous cases of motor disorders.

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✍ Massimo Corbo; M. Kamel Abouzahr; Norman Latov; Sandro Iannaccone; Angelo Quattr πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 417 KB πŸ‘ 2 views

The clinical presentation of motor neuropathy often resembles that of motor neuron disease, sometimes leading to an erroneous diagnosis. Moreover, the underlying pathological process in motor neuropathy has been rarely investigated and there are no systematic studies of the affected motor nerves. We