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Macrocyclic Cyclopropenes by Highly Enantioselective Intramolecular Addition of Metal Carbenes to Alkynes

โœ Scribed by Michael P. Doyle; Doina G. Ene; Chad S. Peterson; Vince Lynch


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
103 KB
Volume
38
Category
Article
ISSN
0044-8249

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g-Hydroxy-a,b-acetylenic esters containing three adjacent and structurally very different functional groups are very useful in the synthesis of highly functionalized organic molecules. [1, 2] This class of compound is normally prepared by treatment of an alkyl propiolate with nBuLi at ร€78 8C