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M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues

✍ Scribed by Verena Puxbaum; Elisabeth Nimmerfall; Christine Bäuerl; Nicole Taub; Pia-Maria Blaas; Johannes Wieser; Mario Mikula; Wolfgang Mikulits; Ken M. Ng; George C.T. Yeoh; Lukas Mach


Book ID
116652775
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
849 KB
Volume
57
Category
Article
ISSN
0168-8278

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The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) suppresses cell growth through binding to the insulin-like growth factor 2 (IGF2) and latent complex of the transforming growth factor-␤ (TGF-␤). Recently, it was reported in the United States that loss of heterozygosity (LOH)