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Mutation analysis of the gene encoding the human mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in human cell lines resistant to growth inhibition by transforming growth factor β1 (TGF-β1)

✍ Scribed by Gemma, Akihiko; Hosoya, Yoko; Uematsu, Kazutsugu; Seike, Masahiro; Kurimoto, Futoshi; Yoshimura, Akinobu; Shibuya, Masahiko; Kudoh, Shoji

Book ID: 118569425
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 176 KB
Volume: 30
Category: Article
ISSN: 0169-5002
DOI: 10.1016/s0169-5002(00)00130-6

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The mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) suppresses cell growth through binding to the insulin-like growth factor 2 (IGF2) and latent complex of the transforming growth factor-␤ (TGF-␤). Recently, it was reported in the United States that loss of heterozygosity (LOH)