M2042 The Role of Pregnane X Receptor (PXR/NR1i2) Gene Variants in Inflammatory Bowel Disease
✍ Scribed by Seiderer, Julia; Glas, Jürgen; Diegelmann, Julia; Fischer, Daniel; Seitz, Barbara; Tillack, Cornelia; Pfennig, Simone; Konrad, Astrid; Wetzke, Martin; Griga, Thomas; Klein, Wolfram; Epplen, Jörg T.; Schiemann, Uwe; Mussack, Thomas; Lohse, Peter; Göke, Burkhard; Ochsenkuehn, Thomas; Folwaczny, Matthias; Müller-Myhsok, Bertram; Brand, Stephan
- Book ID
- 121926277
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 168 KB
- Volume
- 134
- Category
- Article
- ISSN
- 0016-5085
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## Background: The pregnane X receptor (PXR/NR1I2) is an important regulator of xenobiotic metabolism and intestinal integrity. However, there are controversial studies on the role of PXR/NR1I2 in inflammatory bowel disease (IBD). We therefore initiated the largest analysis to date on PXR/NR1I2 ge
## Background: The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We