Lack of association of the pregnane X receptor (PXR/NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis

Investigation of associations between th

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach

✍ Devendra K. Amre; David R. Mack; David Israel; Kenneth Morgan; Alfreda Krupoves; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 2 views

## Background: The pregnane-X-receptor (PXR) is involved in the metabolism and detoxification of numerous xenobiotics and is critical for maintaining intestinal integrity. The NR1I2 gene encoding PXR may confer susceptibility for Crohn's disease (CD) but evidence for associations is conflicting. We