Contribution of increased mitochondrial
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Aaron M. Byrne; John J. Lemasters; Anna-Liisa Nieminen
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Article
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1999
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John Wiley and Sons
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English
β 356 KB
Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc