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m-Iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes

✍ Scribed by Marlene J. Juedes; George E.N. Kass; Sten Orrenius


Book ID
115926853
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
314 KB
Volume
313
Category
Article
ISSN
0014-5793

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Previously, we showed that the oxidant chemical, tert-butylhydroperoxide (t-BuOOH), induces a mitochondrial permeability transition (MPT) in intact hepatocytes, causing lethal cell injury. Here, we investigated the role of mitochondrial free Ca2+ in t-BuOOH cytotoxicity to 1-day-cultured rat hepatoc