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The Ca2+-calmodulin-Ca2+/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes

✍ Scribed by Toledo, Flavia D.; Pérez, Leonardo M.; Basiglio, Cecilia L.; Ochoa, Justina E.; Sanchez Pozzi, Enrique J.; Roma, Marcelo G.


Book ID
124078589
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
778 KB
Volume
88
Category
Article
ISSN
0340-5761

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## Abstract Hyperglycemia and acidosis are the key factors in diabetic complications. It has been shown that acute or chronic diabetes alters serotonin levels in brain. However, the mechanism of hyperglycemia‐ or acidosis‐induced changes in serotonin levels remains poorly understood. Because Ca^2+^