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Lysosomes of rat liver and dab carcinogenesis

✍ Scribed by Tatsuya Takano; Nobuo Kato; Setsuko Kunimoto-Miyata; Sataro Goto; Shoji Ohkuma; Den'ichi Mizuno; Tomoyuki Kitagawa; Takeshi Yokoyama

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
539 KB
Volume
7
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The relationship between DAB carcinogenesis and changes of lysosomes in rat liver was investigated. After 40 days of treatment with DAB, nodules and an abnormal cell population, containing small, large and degenerative cells, appeared. Corresponding to these changes, the S/P ratio of lysosomal enzymes such as acid RNase and β‐glucuronidase increased to two or three times the normal value. These alterations were considered along with some histochemical observations on β‐glucuronidase. A possible participation of these lysosomal enzymes in carcinogenesis is discussed.

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