Lysosomes (Medical Intelligence Unit)

✍ Scribed by Paul Saftig

• Publisher: Springer
• Year: 2005
• Tongue: English
• Leaves: 209
• Edition: 1
• Category: Library

✦ Synopsis

Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.

✦ Table of Contents

Cover Page......Page 1
Inside Cover......Page 2
Copyright © 2005......Page 3
Contents......Page 5
Editor, Contributors......Page 9
Preface......Page 11
CHAPTER 1 - History and Morphology of the Lysosome......Page 13
CHAPTER 2 - Transport of Lysosomal Enzymes......Page 29
CHAPTER 3 - Adaptor Proteins in Lysosomal Biogenesis......Page 39
CHAPTER 4 - Lysosomal Membrane Proteins......Page 49
CHAPTER 5 - Lysosomal Proteases: Revival of the Sleeping Beauty......Page 62
CHAPTER 6 - Lysosomal Storage Disorders......Page 72
CHAPTER 7 - Lysosomal Transporters and Associated Diseases......Page 86
CHAPTER 8 - Neuronal Ceroid-Lipofuscinoses......Page 94
CHAPTER 9 - Cholesterol Transport in Lysosomes......Page 112
CHAPTER 10 - Therapy of Lysosomal Storage Diseases......Page 124
CHAPTER 11 - Lysosomal Proteome and Transcriptome......Page 142
CHAPTER 12 - External Lysosomes: The Osteoclast and Its Unique Capacities to Degrade Mineralised Tissues......Page 156
CHAPTER 13 - Membrane Resealing Mediated by Lysosomal Exocytosis......Page 168
CHAPTER 14 - Macroautophagy in Mammalian Cells......Page 178
CHAPTER 15 - Chaperone-Mediated Autophagy......Page 193
Index......Page 206
Back Cover......Page 209