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Lysophosphatidic Acid Induction of Neuronal Apoptosis and Necrosis

✍ Scribed by MARION R. STEINER; FREDERICK W. HOLTSBERG; JEFFREY N. KELLER; MARK P. MATTSON; SHELDON M. STEINER


Book ID
111396462
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
834 KB
Volume
905
Category
Article
ISSN
0890-6564

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The lipid biomediator lysophosphatidic acid (LPA) elicits a unique response in hippocampal neurons, LPA induces neuronal apoptosis. This study explores the effects of LPA on cells with neuronal properties, nerve growth factor-differentiated PC6 cells, a clone of PC12 cells. LPA induced apoptosis in