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Acidosis Induces Necrosis and Apoptosis of Cultured Hippocampal Neurons

✍ Scribed by Ding Ding; Shaye I. Moskowitz; Rong Li; Sean B. Lee; Mariano Esteban; Kevin Tomaselli; Jane Chan; Peter J. Bergold


Book ID
115607201
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
366 KB
Volume
162
Category
Article
ISSN
0014-4886

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## Background Bcl-2 homology domain (BH) 3-only proteins are pro-apoptotic proteins of the Bcl-2 family that couple stress signals to the mitochondrial cell death pathways. The BH3-only protein Bid can be activated in response to death receptor activation via caspase 8-mediated cleavage into a trun