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Lysophosphatidic acid cooperates with 1α,25(OH)2D3 in stimulating human MG63 osteoblast maturation

✍ Scribed by J. Gidley; S. Openshaw; E.T. Pring; S. Sale; J.P. Mansell

Book ID: 113864979
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 538 KB
Volume: 80
Category: Article
ISSN: 0090-6980
DOI: 10.1016/j.prostaglandins.2006.04.001

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## Abstract 1α,25‐dihydroxyitamin D~3~ (1,25D3) deficiency leads to impaired bone mineralization. We used the human pre‐osteoblastic cell line SV‐HFO, which forms within 19 days of culture an extracellular matrix that starts to mineralize around day 12, to examine the mechanism by which 1,25D3 regu