1α,25(OH)2Vitamin D3-Mediated Stimulation of Outward Anionic Currents in Osteoblast-like ROS 17/2.8 Cells
✍ Scribed by Laura P. Zanello; Anthony W. Norman
- Book ID
- 115578880
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 94 KB
- Volume
- 225
- Category
- Article
- ISSN
- 0006-291X
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## Abstract In ROS 17/2.8 rat osteoblastic‐like cells a capacitative Ca^2+^ entry (CCE) pathway operates which is activated by either 1α,25‐dihydroxy‐vitamin D~3~ (1α,25(OH)~2~D~3~) or thapsigargin (Tpg)‐induced depletion of Ca^2+^ stores (Baldi et al. [2002]: J. Cell. Biochem. 86:678–687). In view
We investigated the existence of a capacitative Ca2+ entry (CCE) pathway in ROS 17/2.8 osteoblast-like cells and its responsiveness to 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3]. Depletion of inner Ca2+ stores with thapsigargin or 1,25(OH)2D3 in the absence of extracellular Ca2+ transiently elevated cy